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HER2 expression as a key predictor of CTX susceptibility in KRAS G13D CRC cells G13D To further investigate whether HER2 expression levels are crucial in determining the susceptibility of KRAS G13D CRC cells to CTX, we employed four SW48 ( KRAS WT , HER2 high ) isogenic cell lines harboring different KRAS mutations (SW48 WT , SW48 G12D , SW48 G12V and SW48 G13D ) and generated their corresponding HER2 knockdown clones (WT_shHER2, G12D_shHER2, G12 V_shHER2, and G13D_shHER2)

The ability to dynamically and quantitatively measure such cellular processes in vivo is key to understand the underlying principles and the coordination of redox processes in the context of intact cells

Poor sleep quality not only impairs daytime cognitive and physical functioning but is also associated with anxiety, depression and vasomotor symptoms

It regulates cellular energy metabolism balance (93), and participates in the regulation of multiple biological processes, including glycogen synthesis (94), fatty acid synthesis (95) and mitochondrial biogenesis (96)