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Another group independently also concluded that disability progression and brain atrophy occur earlier than in the classical secondary progressive stage, with many relapsing patients exhibiting insidious progression without clinical or radiographic evidence of inflammatory disease activity, coining the term silent progression (Cree et al., 2019)

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Food and Drug Administration (FDA) to treat hematopoietic complications following acute radiation exposurefilgrastim (Neupogen, Amgen, FDA approved March 2015) (Food and Drug Administration, 2015a), pegfilgrastim (Neulasta, Amgen, FDA approved November 2015) (Food and Drug Administration, 2015b), sargramostim (Leukine, Partner Therapeutics, FDA approved March 2018) (Food and Drug Administration, 2018), and romiplostim (Nplate, Amgen, FDA approved January 2021)

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Tatum JL, Hoffman JM