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Temporal study of acetaminophen (APAP) and S-adenosyl-L-methionine (SAMe) effects on subcellular hepatic SAMe levels and methionine adenosyltransferase (MAT) expression and activity

Weeks 1-2: 5 units per injection (0.5 mg) Weeks 3-8: 8 units per injection (0.8 mg) Frequency: Once daily, 5 days on, 2 days off Timing: Morning injection Cycle length: 2 months active, 2 months off The ramp-up is intentional

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