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In turn, enhancing KCC2 activity not only potentiated L838,417-induced analgesia, it rescued its analgesic potential at high doses, revealing a novel strategy for analgesia in pathological pain, by combined targeting of the appropriate GABA A R-subtypes and restoring Cl - homeostasis

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Prior to irradiation, the reactants were shaken for 20 min and kept for an hour to achieve equilibration

Its extreme short half-life (minutes) means intranasal or oral routes without modification are ineffective due to rapid degradation

Finally, emphasis was given to the possible integration of the nanoparticles with other emerging technologies for the symptomatic management of PD