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BonekampNAJiangMMotoriEGarcia VillegasRKoolmeisterCAtanassovIet alHigh levels of TFAM repress mammalian mitochondrial DNA transcription in vivo

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In rats, acute treatment with TMAO specifically impairs acetylcholine-evoked EDH-mediated relaxation in the femoral arteries, indicating that TMAO contributes to the progression of peripheral arterial disease [98]