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Symptoms often include fatigue, weakness, and neurological problems

The metabolic pathway with the strongest (by pathway impact) and most significant changes during reprogramming was glycine (Gly), serine (Ser), threonine (Thr) metabolism (Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway map00260

However, paresthesias is also a common symptom of nerve damage caused by high blood sugar in people with diabetes this is called diabetic peripheral neuropathy