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PMID: 29165784

For a POTS patient, simply changing posture can result in a skyrocketing heart rate, palpitations, tremors, and a profound sense of panic or anxietyoften referred to in the patient community as an "adrenaline dump." The body is trapped in a perpetual state of hyper-arousal, which is incredibly draining and contributes significantly to the profound fatigue seen in these conditions

Quantitative analysis was performed via external calibration with linearity established through peak area-concentration plots of standard solutions

The metaphor of awakening sluggish or dormant neurons can be misleading