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In the process, superficial hyperpigmented cells begin to die, to make way for new cells formed in the skins matrix, resulting in lighter-looking skin

Zhou, X., Wang, G., Wu, Y., Wu, M., Zhai, X., Tian, C., Prochownik, E

Using the FDA's body-surface-area conversion, a 10 mcg/kg rat dose maps to roughly 1.6 mcg/kg in a human, but most practitioners use higher doses based on clinical experience

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