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42 Research has found that folate concentrations in plasma and red cells in diabetic individuals with both proliferative diabetic retinopathy and non-proliferative retinopathy were significantly lower than both healthy subjects and diabetic patients without retinopathy

However, for significant tissue repair and more substantial benefits, a longer treatment course of several weeks to months may be necessary

Overman MJ, Lonardi S, Leone F, McDermott RS, Morse MA, Wong KYM, Neyns B, Leach JL, Garcia Alfonso P, Lee JJ, Hill A, Lenz HJ, Desai J, Moss RA, Cao ZA, Ledeine JM, Tang H, Kopetz S , Andre T