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Article contents Abstract Introduction Allostery: Theoretical framework of conformational behavior Dynamic communication networks and functional specificity Signaling bias not only in GPCRs but also in all dynamic, allosteric proteins GPCRs and dynamic allosteric proteins share signaling principles Conclusions Author contribution Competing interests References Allostery: allosteric networks and allosteric signaling bias Published online by Cambridge University Press: 18 November 2025 Abstract Introduction Allostery: Theoretical framework of conformational behavior Dynamic communication networks and functional specificity Signaling bias not only in GPCRs but also in all dynamic, allosteric proteins GPCRs and dynamic allosteric proteins share signaling principles Conclusions Author contribution Competing interests References Abstract Allosteric communication is established by networks through which strain energy generated at the allosteric site by an allosteric event, such as ligand binding, can propagate to the functional site

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Effect of Epitalon on age-related changes of the neuroendocrine-immune system and tumor development Summary: This review discusses how Epitalon, by influencing the pineal gland, can modulate the neuroendocrine-immune system and thereby affect age-related diseases, including cancer