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To determine whether NQO1 transgenesis elicited beneficial effects on insulin sensitivity in vivo, we performed hyperinsulinemiceuglycemic clamp after 16 weeks on diet (Fig

First, because 4MP causes considerable phospho-JNK inhibition which negatively impacts p53 activation and necrosis 92 , we considered that 4MP causes a conservative 80% decrease of p53 activation and simulated this by multiplying the phosphorylation rate of p53 with parameter k 4MP JNK = 0.2 (i.e., decreasing the phosphorylation rate)

*IV Ketamine, NR, and NAD+ have been used clinically off-label for decades

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