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Figure 5 Proof of concept experiments that support the hypothesis of chronic glutamate toxicity in neurodegeneration As EAATs have been found to be down-regulated in many diseases of the nervous system (Sheldon and Robinson, 2007) and hypothetically increased L-glu and L-asp clearance should dampen the excitotoxic component of these diseases, many researchers have set out to identify compounds that induce EAAT2, which is the principal EAAT in the brain and most frequently found to be downregulated (Sheldon and Robinson, 2007

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3 Notably, Hb was detected within the nucleus marker (DAPI)-stained nucleus region but was primarily clustered in DAPI-negative subnuclear regions (Fig

Although they are usually characterized as M2-like, there may be M1-like TAMs as well, according to some data

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