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Much of the evidence comes from laboratory and animal studies, so benefits in humans are not guaranteed

Estrogen therapy is known to have a protective role against neurodevelopmental disorders and glutamate-induced neurotoxicity via the mTOR pathway [125]

Differences in diagnosis accuracy, inflammatory load, sleep, metabolic health, and biomechanics can make the same therapy look powerful in one person and ineffective in another

They show that a system that is farther away from the target can reach this target faster than another one that is closer to the target. Yet not everyone is entirely persuaded that the Mpemba effect has been demonstrated in any system

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