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Lower doses are often effective in enhancing sleep quality

7-Hydroxymitragynine (7-HMG) is a mitragynine metabolite that is a more potent and efficacious opioid than its parent mitragynine

Neuroscience 145 , 185196 (2007)

GO enrichment analysis showed that the upregulated DEGs were mainly enriched in apoptosis, inflammation, and oxidative stress, while the downregulated DEGs were primarily involved in gap junctions, cell proliferation, and sex hormone response (Figure 3B), suggesting that the damage to granulosa cell function, including increased apoptosis and decreased proliferation ability, may be a critical cause of follicular atresia and oocyte maturation disorders