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These mechanisms collectively reduce estradiol levels and destabilize the hypothalamic-pituitary-ovarian axis, resulting in irregular cycles and a more symptomatic perimenopause (Matikainen et al., 2001)

doi: 10.1210/endo.132.6.8504756

doi: 10.3389/fphar.2024.1325283 171 BaiXLiuZTangTYuSLiuDLiuGet al

Bardoxolone methyl improves survival and reduces clinical measures of kidney injury in tumor-bearing mice treated with cisplatin

In conclusion, breast cancer, being one of the most common cancers in women, remains the subject of scientific and clinical research, requiring more focused research for better understanding, prevention, and treatment of breast cancer