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The inhibition of HDAC3 mitigates the abnormal expression of -smooth muscle actin (-SMA), collagen-1, E-cadherin, and bone morphogenetic protein 7 (BMP-7) to mitigate tubular injury and interstitial fibrosis induced by UUO/AAN treatment

For example, Astragalus polysaccharide (APS) was shown to inhibit the formation of the pre-metastatic niche in lung cancer by blocking the S1PR1/STAT3 signaling pathway, thereby preventing metastasis when used alongside standard treatment (143)

On the other hand, it is also clear that prolonged LC supplementation elevates fasting plasma TMAO [16,17,18, 58, 59], compound supposed to be pro-atherogenic [61]

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However, there were no significant differences observed between NAC and NACET treated animals (Fig