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Nrf2 improves endothelial function by resisting oxidative stress and mitochondrial damage, thereby delaying atherosclerosis (245)

We would not expect a close match to the clinically observed percentage changes because we are comparing intracellular model changes to blood measurements

(2023, accessed 13 Jan 2023)

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Although ADCs with higher DARs have expectedly greater in vitro potency, preclinical studies suggest that they may be subject to more rapid hepatic clearing and a less favorable safety profile, eventually lowering their therapeutic index [18]