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Endothelin receptor antagonists Activation of the endothelin A receptor by endothelin-1 has been widely recognized as a key pathophysiological mechanism contributing to the onset and progression of CKD through multiple processes, including vasoconstriction, podocyte injury, inflammation, and fibrosis [173]

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(The Copolymer 1 Multiple Sclerosis Study Group) Copolymer 1 reduces relapse rate and improves disability in relapsing-remitting multiple sclerosis: results of a phase III multicenter, double-blind placebo-controlled trial