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Ligand immobilization was carried out in flow cell 2 with a series of ligand injections at a flow rate of 5 L/min, until the desired density was achieved (700 RU for ENL_YEATS ternary complex, 1800 RU for ENL_YEATS small molecule binding and 4430 RU for CRBN midi )

Chem Res Toxicol 7: 519525

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Experimental and Toxicologic Pathology, 63(1), 167173

Based on the above assumptions, we propose a novel potential intervention strategy: targeting GPX3 and MYC by modulating specific gut microbiota metabolites (such as Diosgenin and DIF-3), thus achieving multi-level regulation of the RA pathological process