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KLOW is the more relevant blend when rosacea-pattern inflammation is present because KPV inhibits NF-B signaling. Reported redness changes may precede collagen-related changes, but no controlled trial has evaluated KLOW for rosacea

Vitamin B12 plays a foundational role in red blood cell production, neurological function, DNA synthesis, and energy metabolism

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Funding This work was supported by the Shanghai Sixth Peoples Hospital Clinic Research Project (ynhg202103) to Yuanyuan Xiao

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