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Due to their numerous elements, TCM effects are not dependent on a singular antiviral mechanism but instead involve the simultaneous presence and interplay of various mechanisms

Mukherjee S, Baidoo J, Fried A, Atwi D, Dolai S, Boockvar J, et al

* Correspondence: Ya-Jane Lee, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Our lab previously determined the crystal structures of ME2, revealing that the structure of the ME2_R67Q mutant was an inactivating dead form of the enzyme, whereas the structure of ME2_R484W was an overactivating closed form 44