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Additionally, CD3+ immune cell depletion via a-CD3 antibody especially in the -M-POU2F1 model reversed the phenotype, suggesting a strong immune dependence of these TFs in promoting tumor clearance

Clinical description All patients with 5-oxoprolinase deficiency have been identified because of 5-oxoprolinuria (4 to 10 g/day

However, the high total-body content of glutathione (probably in the range of 40 to 80 gm in a 70 kg adult) and the relatively short half-life of this reactive and metabolically important compound (4 to 10 hours in most tissues) render glutathione replacement extremely difficult to achieve in practice

Identification of novel antioxidant gene signature to predict the prognosis of patients with gastric cancer

doi:10.1007/s13300-019-0619-1 33