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Assuming a truncated normal or lognormal distribution, large gaps between the lowest reported concentrations and the LOQ may indicate the need for additional validation experiments at the low concentration range (Pleil et al

& Groenendaal, F

J Allergy Clin Immunol 88(5):784792 Empedrad R, Darter AL, Earl HS, Gruchalla RS (2003) Nonirritating intradermal skin test concentrations for commonly prescribed antibiotics