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Furthermore, a study evaluated the effectiveness of free and nanoparticle-encapsulated EGCG in treating HD symptoms in mice

doi: 10.3389/fnagi.2022.879021 12 BloomG

Fifteen randomized controlled trials (RCTs) involving 1,123 adult participants were included

*Correspondence: Yelena Budovskaya and Hans van der Spek, Swammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, Amsterdam 1098 XH, Netherlands

Part of FOXO3a is phosphorylated and translocated from the nucleus to the cytoplasm, where it regulates important physiological processes such as energy metabolism, cell apoptosis, and oxidative stress and is ultimately degraded, preventing cell apoptosis (221, 222)