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In preclinical models, BPC-157 is investigated for its activity across several interconnected signaling cascades, including the VEGFR2/eNOS angiogenic axis, the FAK-paxillin pathway in tendon fibroblasts, and ERK1/2-mediated transcription factor activation

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We thank the late Rebecca Sitsapesan for useful discussions at the start of this project

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Due to the possibility of ROS, RNS and RCS being present in the phagocytic vesicles, glutathione dimers to form oxidized glutathione disulfide (GSSG), which does not bind to PrfA

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