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Ortho-Vanillin, a simple phenolic compound isolated from Vanilla planifolia and Pinus koraiensis, did not alter TLR2 expression but inhibited the interaction between TLR2 and its adaptor protein MyD88

Oh et al., 2024

This can be achieved by using PD-1 blockade antibodies or modified CAR-T cells that secrete PD-1 blockade single-chain variable fragments (scFv) in PD-L1+ hematological and solid tumor clinically relevant syngeneic and xenograft mouse models (179), which can increase glucose concentration in TME to favor T cell glycolysis and the production of IFN- ( Figure 1 )