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Notably, the azo-containing chemotherapeutic drug procarbazine for the treatment of Hodgkins lymphoma and brain cancers was found to interact through a similar mechanism of action involving the transformation of GSH to GSSG and regeneration of the catalyst through a reaction with O 2 38,39 , providing feasibility of the proposed catalysis

doi: 10.1016/s0092-8674(00)81674-8 23 BrerS

As an example, GSH depletion has been shown to promote pro-inflammatory microglial phenotypes and amplify astrocyte-microglia crosstalk (Vilhardt et al., 2017)

revealed that the expression of molecules responsible for sustaining immune memory in the human BM undergoes age-related alterations

24 h after the treatment, cells were fixed with 10% trichloroacetic acid, extensively washed, then incubated with the dye, washed and finally resolubilized in 10 mM Tris base, prior to scanning the plates at 565 and 690 nm (main signal and background, respectively)