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It is always wise to start with a lower dose and see how your body responds before increasing it

The high efficiency of superoxide dismutase seems necessary: even at the subnanomolar concentrations achieved by the high concentrations of SOD within cells, superoxide inactivates the citric acid cycle enzyme aconitase, can poison energy metabolism, and releases potentially toxic iron

doi: 10.1007/s13205-019-1999-7