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Additionally, copper-related DNA methylation alterations are linked to an elevated risk of acute coronary syndrome, suggesting an epigenetic role in the disease [197, 198]

Ivanova D, Zhelev Z, Semkova S, et al

Recent studies have demonstrated that primary and secondary sites can communicate through exosomes, shed not only by the primary tumor cells, but also by the immune and stromal cells such as NK cells, CAFs and dendritic cells [19]