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The liver contains the highest concentration of these enzymes, which is consistent with its primary function as receptor of the majority of the xenobiotics absorbed by the organism

FasL promotes the tumor-specific exclusion of cytotoxic T-cells, facilitates the formation of an immunosuppressive TME, and leads to the development of drug resistance 71 ( Figure 3G )

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In recent years, the pathogenic role of iron overload in cardiotoxicity has been widely recognized

reported that riboflavin deficiency impaired the function of the mitochondrial electron transport chain and activated the expression of PPAR gene [53], implying that riboflavin deficiency may affect lipid metabolism by altering the expression of PPAR gene