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Reference Brack, Werner, et al

rosea operates through BDNF/TrkB signaling pathways, serotonergic modulation, and neuroprotective mechanisms, underscoring its potential as a safe and efficacious alternative or adjunctive treatment in the management of depression

When storage capacity is exceeded, excess fatty acids spill into the circulation, accumulate in non-adipose tissues, and promote lipotoxic pathology (98, 99)

Importantly, these epigenetic alterations have been shown to persist beyond the period of active androgen exposure, even after partial normalisation of circulating hormone levels