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1C, geometric mean titers (GMTs) for neutralization of combination group were 6.27-fold, 3.45-fold, and 4.1-fold higher against WT (D614G), B.1.1.7 (Alpha), and B.1.617.2 (Delta), respectively, and 2.77-fold, 5-fold, and 5.3-fold higher against the Omicron variant (BA.1, BA.2, and BA.2.75) than the vaccine alone group

doi: 10.3390/msf2021005004 82

First-line treatment is a macrolide antibiotic, which decreases transmission by eradicating the nasopharyngeal organism but does not alter the clinical course once paroxysms begin