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Various pathways contributing to dopaminergic neuron loss in PD have been investigated and described to interact with the innate and adaptive immune system

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Zinc helps induce metallothioneins the body's own metal-binding proteins and is useful where copper runs high

PDG2 and its conversion product 15d-PGJ2 are neuroprotective by reducing NF-B activation, decreasing proinflammatory genes and by activating the transcription factor PPARgamma (45)