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In line with this, scientists at UCB demonstrated that the Fab of the anti-FcRn mAb rozanolixizumab could be expressed in a range of non-classical Ab formats with only one Fab, as opposed to the two found in classical bivalent IgGs, and retain the ability to shorten the plasma half-life of exogenously administered human IgG in human FcRn transgenic mice [124]

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12 In 1999, the results of a large trial including 305 patients was published, showing control of menorrhagia in 86% of the cases at 3 months and 92% at 12 months

while GR rescues GSH by endorsing the conversion of GSSG (glutathione disulfide) into GSH, which forms during radical scavenging reactions of GSH [50, 51]