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75 These techniques, however, could not detect DNA interstrand cross-linking in mammalian cells exposed to therapeutic levels of alkylating agents in vitro or in tissues after in vivo drug administration

doi: 10.1159/000380771 107 ChalmersJDGoeminnePAlibertiSMcDonnellMJLonniSDavidsonJet al

In the context of SSMD, ensuring that scientists have identified and can agree on the appropriate ortholog to human GPX4 for manipulation is critical, and as a selenoprotein GPX4 presents further challenges across other species

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Benzene and its phenolic metabolites produce oxidative DNA damage in HL60 cells in vitro and in the bone marrow in vivo Cancer Res 1993 53 : 10231026 Lvay G, Bodell WJ