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In short, giving B12 to special groups needs a careful plan

Kolomin T, Shadrina M, Slominsky P, et al

Prkacin I, Separovic J, Aralica G, et al

& Singleton, A

For example, opioids decrease pulmonary perfusion via hypoxia-induced pulmonary vasoconstriction 143 , and by direct pulmonary vasoconstriction 144,145 by mechanisms including centrally-mediated activation of sympathetic nerve activity to the lungs 146 , and induction of histamine release in the lungs 144,147