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SIRT1 induces the circadian transcription of core clock genes, such as Cry1, Per2, Ror, and Bmal1 via either rhythmically deacetylating BMAL1 or PER2

MIP analysis The MIP detection in tomograms was performed using an in-house workflow based on the procedure described previously 43 and the scheme given in Extended Data Fig

Polarization was also assessed at the ultrastructural level, revealing features of primary liver tissue, including epithelial cells lining luminal structures arranged in a layer and connected by tight junctions, a feature of the hematobiliary barrier (Fig

In addition, certain medical conditions and medications can cause vitamin B12 deficiency (30)