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doi: 10.3389/fonc.2023.1116438 115 ChoudharyGSPellagattiAAgianianBSmithMABhagatTDGordon-MitchellSet al

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In most microbes prephenate is first converted into 4-hydroxyphenylpyruvate (HPP) by a NAD + -dependent prephenate-specific TyrA dehydrogenase (PDH/TyrA p ), followed by transamination to form Tyr (Figure 1) (Jensen and Pierson, + -dependent arogenate-specific TyrA dehydrogenase (ADH/TyrA a ) (Gaines et al., 2002)