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Cella D, Escudier B, Tannir NM , Powles T, Donskov F, Peltola K, Schmidinger M, Heng DYC, Mainwaring PN, Hammers HJ, Lee JL, Roth BJ, Marteau F, Williams P, Baer J, Mangeshkar M, Scheffold C, Hutson TE, Pal S, Motzer RJ, Choueiri TK

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It is supported by this hypothesized mechanism by one longitudinal clinical cohort study: serum ROS levels were associated with joint space narrowing and its 5-year progression

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It has been demonstrated that fatty acid derived -OHB specifically activates HCAR2 receptors within physiologically relevant -OHB concentrations (K i = 0.7 mM) (Taggart et al., 2005), typically observed in serum during short-term fasting