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An increase might have been observed in the tibial area bone mineral density (BMD, which is the ratio of BMC to area), but the total and vertebral area BMDs seem to have remained consistent

J Neural Transm 121:12691272 [DOI] [PubMed] [Google Scholar] Liu D, Ke Z, Luo J (2017) Thiamine deficiency and neurodegeneration: the interplay among oxidative stress, endoplasmic reticulum stress, and autophagy

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By contrast, the International Lyme and Associated Diseases Society (ILADS) have issued markedly different clinical recommendations focused on often open-ended antibiotic treatment of persistent infection and the potential for multiple tick-borne co-infecting agents (162)

There is also no guarantee that these pens are being blended, filled, or stored in sterile conditions, introducing a risk of blood-borne infections, localised tissue necrosis and systemic sepsis