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Third, microbiota-dependent and microbiota-independent mechanisms should be disentangled using targeted mechanistic designs, for example, antibiotic depletion, fecal microbiota transplantation, gnotobiotic or defined-consortium models, and metabolite supplementation, supported by paired multiomics that link microbial functions and metabolites to host pathways

Curhan 2004)

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The most used nutritional strategy regardless of whether the animals are omnivores or carnivores is the reduction of carbohydrates

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