Journal of Cosmetic Dermatology, 9(3), 191198
The failure of antioxidant systems, particularly glutathione peroxidase 4 (GPX4), which reduces lipid hydroperoxides to non-toxic lipid alcohols, leads to the collapse of membrane integrity and ferroptotic cell death ( A central regulator of ferroptosis and oxidative stress responses is nuclear factor erythroid 2-related factor 2 (Nrf2), a transcription factor that controls the expression of a wide array of antioxidant and cytoprotective genes
[DOI] [PMC free article] [PubMed] [Google Scholar] [127].Gautheron J, Vucur M, Reisinger F, Cardenas DV, Roderburg C, Koppe C, Kreggenwinkel K, Schneider AT, Bartneck M, Neumann UP, Canbay A, Reeves HL, Luedde M, Tacke F, Trautwein C, Heikenwalder M, Luedde T
These studies concluded that the RLA--CD enhances the dissolution of RLA in small intestine lumen which leads to increased absorption in the intestine (Uchida et al ., 2015)
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