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Ruberti, 00185 Rome, Italy 2 Experimental Neuroscience and Neurological Disease Models, Santa Lucia Foundation IRCCS, 00143 Rome, Italy These authors contributed equally to this work

*Correspondence: Bernard Crespi, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Affinity-based chemistries such as biotin-streptavidin binding and carbodiimide coupling are also used