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This may affect any of the six circuits of the NEM system

doi: 10.1016/j.molcel.2021.08.027 119 BalabanSLeeLSSchreuderMHoyAJ

We questioned whether chronic stress may exacerbate phenotypes and found that chronic stress significantly resulted in increased phosphorylated, insoluble TDP-35 fragments which then recovered upon removal of stress

ACTL6A impacts GSH de novo synthesis mainly by upregulating -glutamyl-cysteine synthesis To further assess the mechanism by which ACTL6A regulates GSH metabolism, we investigated the metabolic fate of U- 13 C glucose by liquid chromatography with mass spectrometry (LCMS), which produces -GC containing two 13 C atoms via GSH de novo synthesis pathway, GSH containing two 13 C atoms via GSH de novo synthesis or the SGOC pathway, or four 13 C atoms via both pathways (Fig

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