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Baillie and Kassahun (1994) state that it seems likely that many xenobiotics with carbamate, formamide, urea, or sulfonylurea functionalities will undergo metabolic transformation to reactive isocyanates and that reversible conjugation to the latter short-lived, potentially toxic intermediates with GSH may play an important role in mediating the disposition and adverse effects of the parent compounds in vivo. 10.17.5.2

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