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Nature Metabolism, 1 (1), 47

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LATLINE was used to obtain equidistant samples along the adapted lattice line curves (Supplementary Fig

Lipid peroxidation occurs when ROS attacks the polyunsaturated fatty acids (PUFAs) in cell membranes, compromising membrane permeability and structural integrity [67,68,69]

In contrast, probiotic intervention antagonizes ferroptosis through mechanisms such as reducing inflammation, repairing intestinal barrier, releasing antimicrobial peptides (cAMPs), regulating iron overload, and inhibiting lipid peroxidation (182, 183), thereby ameliorating the pathological phenotype of IBD ( Figure 3 )