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Presynaptic development was similar in both genotypes as assayed by quantification of synapsin-positive punctae (at DIV21, Nbea +/+ : 23.401.97 punctae per 10 m dendrite length, n =7 cultures

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A possible mechanism at a neuronal level could be that stimulation of mu-opioid receptors suppresses interneuron spiking and increases glutamate-coded output of prefrontal neurons at multiple projection targets, which in turn might engender disorganized control and decision processes (Baldo, 2016)

This is most common in the first trimester, though I experienced it in the early weeks of my second trimester as well

BPC-157 | Zenith Bioscience