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Ren W, Lui S, Deng W, Li F, Li M, Huang X, et al

Structural basis for helicase-polymerase coupling in the SARS-CoV-2 replication-transcription complex

In this context, Hcy serves as a substrate for methionyl-tRNA synthetase (MARS), which catalyzes its conversion into homocysteine thiolactone (HTL), a highly reactive metabolite with enhanced cytotoxicity[14]