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For CJC-1295 with DAC, timing is less critical due to the extended half-life, though many researchers prefer evening administration

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Nature 433 , 7377 (2005)

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Disclosures: Babu Lal Meena: Nothing to Disclose, Shiv Kumar Sarin: Nothing to Disclose, Deepti Sharma: Nothing to Disclose 592 FIRST-IN-HUMAN PHASE 1 STUDY OF EA3571, WHICH IS A NOVEL DUAL INHIBITOR OF ENTEROPEPTIDASE AND TRYPSIN WITH LUMINAL ACTION, IN HEALTHY ADULT PARTICIPANTS ATSUSHI UMEDA 1 YASUKO OWADA 2 KENICHI FURIHATA 3 SHUICHI TSURUOKA 4 Atsushi Nakajima 5 RYOSUKE MIKAMI 6 MASAKAZE OAKU 1 TAKUYA YAMAMOTO 1 TETSUO YANO 1 YUJI KUMAGAI 7 , 1 EA Pharma Co., Ltd., 2 OPHAC Hospital, 3 P-one Clinic, 4 Tajirigaoka Hospital, 5 Yokohama City University, 6 EA Pharma Co., Ltd, 7 Kitasato Institute Hospital Background: EA3571 is a novel dual inhibitor of enteropeptidase and trypsin with luminal action