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IGF-IR inhibitors resistance The high failure rate of anti-IGF-IR mAb/inhibitor monotherapy or combinational therapy in clinical trials promotes the investigators to inspect the mechanisms underlying resistance to IGF-IR inhibition in cancer and revisit the strategies to target IGF-IR pathway

SCD1 regulates the stemness of CSCs through the Wnt/-catenin pathway

Saliva might be employed as a non-invasive diagnostic fluid to measure biomarkers released during the course of a disease (45-47), including indicators of oxidative processes (48)

However, malnutrition and starvation are difficult to assess clinically and in particular protein-calorie malnutrition can co-exist with chronic alcohol use and with inter-current acute or chronic illness, which may independently or in concert increase the risk of paracetamol toxicity and confound the assertion that malnutrition per se increases the risk of paracetamol toxicity [6, 16, 73, 78,79,80,81,82,83]

[DOI] [PMC free article] [PubMed] [Google Scholar] 252.Yang K, et al